周焕斌，男，籍贯湖北武汉，中国农业科学院研究员、博士生导师。

2000年和2003年在华中农业大学园艺林学学院分别获蔬菜学学士和硕士学位，2007年在中国科学院遗传与发育生物学研究所获遗传学博士学位。2007至2015年分别在美国加州大学河滨分校植物病理与微生物学系、爱荷华州立大学遗传发育与细胞生物学系从事博士后研究工作。2015年4月回国，入职长相思。2017年入选中国农科院“青年英才A类”，2019年入选国家高层次人才特殊支持计划青年项目，同年入选中国农科院“农科英才领军人才B类”。目前兼任中国植物病理学会常务理事、副秘书长；中国作物学会分子育种分会理事；中国生物工程学会生物农业分会理事；BMC Plant Biology和Frontiers in Genome Editing杂志Associate editor、生物技术通报编委。

研究组承担国家自然科学基金、国家重点研发计划专项、国家转基因重大专项、国家农业重大科技项目等项目多项。主要从事基因组编辑技术开发与植保相关应用，涉及1）病原微生物基因组编辑技术开发，阐述病原菌致病机理以及创制高活性工程菌株；2）作物基因组编辑技术开发和分子精准育种新方法研究，发掘抗病、耐除草剂等重要功能基因资源，培育基因组编辑抗性水稻新材料和新品种，为实现我国农业绿色植保和可持续发展提供重要支撑。目前已获得国家发明专利授权7项，在Cell Host & Microbe, Nucleic Acids Res, Genome Biol, Mol Plant, Plant Biotech J, Plant Physiol, Plant J, PLoS Pathog等国内外重要学术期刊上发表论文40多篇，其中8篇为ESI高被引论文，总引用率达2800多次。

联系方式：zhouhuanbin@caas.cn

个人网址：https://www.researchgate.net/profile/Huanbin_Zhou

代表性论文（#通讯作者）

1. B Ren, Y Kuang, Z Xu, X Wu, D Zhang, F Yan, X Li, X Zhou, G Wang^# & H Zhou^#. Three novel alleles of  OsGS1 developed by base-editing-mediated artificial evolution confer glufosinate tolerance in rice.  Crop J . 2023, https://doi.org/10.1016/j.cj.2022.10.003.

2. F Yan, J Wang, S Zhang, Z Lu, S Li, Z Ji, C Song, G Chen, J Xu, J Feng, X Zhou & H Zhou^#. CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates.  PLoS Pathog . 2023, 19(1): e1010961.

3. S Li^#, C Wang, C You, X Zhou & H Zhou^#. T-LOC: A comprehensive tool to localize and characterize the T-DNA integration sites.  Plant Physiol.  2022, 190(3):1628-1639.

Commented by G Alex Mason. T-LOCked in: Identifying T-DNA insertions in plant genomes.  Plant Physiol . 2022, 190(3):1547-1549.

4. S Li^#, L Liu, W Sun, X Zhou & H Zhou^#. A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants.  Genome Biol . 2022, 23: 51.

5. K Wang*, H Zhou*& Q Qian^#. The rice codebook: from reading to editing. Mol. Plant . 2022, 15: 569-572.

6. G Gosavi, B Ren, X Li, X Zhou, C Spetz^# & H Zhou^#. The new era of creating herbicide-tolerant crops through genome editing.  ACS Agr Sci. & Technol . 2022, 2: 184-191.

7. G Ma, Y Kuang, Z Lu, X Li, Z Xu, B Ren, X Zhou & H Zhou^#. CRISPR/Sc++ system-mediated genome modification in rice.  J Integr Plant Biol . 2021, 63: 1606-610.

8. D Yan, B Ren, L Liu, F Yan, S Li, G Wang, W Sun, X Zhou & H Zhou^#. High-efficiency and multiplex adenine base editing in plants using new TadA variants.  Mol. Plant. 2021, 14(5): 722-731. （ESI高被引论文）

9. Z Xu, Y Kuang, B Ren, D Yan, F Yan, C Spetz, W Sun, G Wang, X Zhou^# & H Zhou^#. SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition.  Genome Biol.  2021, 22: 6. （ESI高被引论文）

10. L Liu, Y Kuang, F Yan, S Li, B Ren, G Gosavi, C Spetz, X Li, X Wang, X Zhou & H Zhou^#. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of  OsTubA2 .  Plant Biotech. J.  2021, 19(1): 5-7.

11. G Gosavi, F Yan, B Ren, Y Kuang, D Yan, X Zhou & H Zhou^#. Applications of CRISPR technology in studying plant-pathogen interactions: overview and perspective.  Phytopathol. Res. 2020, 2: 21.

12. M Wang, Z Xu, G Gosavi, B Ren, Y Cao, Y Kuang, C Zhou, C Spetz, F Yan, X Zhou & H Zhou^#. Targeted base editing in rice with CRISPR/ScCas9 system.  Plant Biotech. J. 2020, 18(8): 1645-1647.

13. Y Kuang, S Li, B Ren, F Yan, C Spetz, X Li, X Zhou & H Zhou^#. Base-editing-mediated artificial evolution of  OsALS1 in planta to develop novel herbicide-tolerant rice germplasms.  Mol. Plant  2020, 13(4): 565-572. (ESI高被引论文)

14. B Ren, L Liu, S Li, Y Kuang, J Wang, D Zhang, X Zhou, H Lin^# & H Zhou^#. Cas9-NG greatly expands the targeting scope of the genome-editing toolkit by recognizing NG and other atypical PAMs in rice.  Mol. Plant  2019, 12(7): 1015-1026. （ESI高被引论文）

15. J Long, C Song, F Yan, J Zhou, H Zhou^# & B Yang^#. Non-TAL effectors from  Xanthomonas oryzae pv.  oryzae suppress peptidoglycan-triggered MAPK activation in rice.  Front. Plant Sci.  2018, 9: 1857.

16. F Yan, Y Kuang, B Ren, J Wang, D Zhang, H Lin, B Yang, X Zhou & H Zhou^#. Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice.  Mol. Plant  2018, 11(4): 631-634. （ESI高被引论文）

17. B Ren, F Yan, Y Kuang, N Li, D Zhang, X Zhou, H Lin^# & H Zhou^#. Improved base editor for efficiently inducing genetic variations in rice with CRISPR/Cas9-guided hyperactive hAID mutant.  Mol. Plant 2018, 11(4): 623-626. （ESI高被引论文）

18. B Ren, F Yan, Y Kuang, N Li, D Zhang, H Lin^# & H Zhou^#. A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice.  Sci. China. Life Sci.  2017, 60(5): 516-519. （第二届中国科协优秀科技论文遴选计划入选论文; SCLS BEST PAPER-2020）  

19. H Zhou, B Liu, DP Weeks, MH Spalding & B Yang^#. Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice.  Nucleic Acids Res  . 2014, 42(17): 10903-10914. （ESI高被引论文）

20. H Zhou, J Lin, A Johnson, RL Morgan, W Zhong & W Ma^#. Pseudomonas syringae  type III effector HopZ1 targets a host enzyme to suppress isoflavone biosynthesis and promote infection in soybean.  Cell Host & Microbe  2011, 9(3): 177-186.

Commented by Andrew Bent. Pathogens Drop the Hint: Don't Forget Phytoalexin Pathways.  Cell Host & Microbe  .  2011, 9(3):169-70.

21. H Zhou, S Li, Z Deng, X Wang, T Chen, J Zhang, S Chen, H Ling, A Zhang, D Wang^# & X Zhang^#. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in the wheat hypersensitive response to stripe rust fungus infection.  Plant J. 2007, 52(3): 420-434.

专利成果：

1. 周焕斌，严芳，任斌，中国发明专利，ZL 2021 1 00612012。

2. 周焕斌，严芳，任斌，闫大琦，柳浪，中国发明专利，ZL 2020 1 1308944.7。

3. 周焕斌，旷永洁，任斌，中国发明专利，ZL 2020 1 0048142.0。

4. 周焕斌，柳浪，中国发明专利，ZL 2018 1 1320030.5。

5. 周焕斌，严芳，旷永洁，中国发明专利，ZL 2018 1 0069129.6。

6. 周焕斌，旷永洁，严芳，中国发明专利，ZL 2017 1 1294415.4。

7. 周焕斌，严芳，中国发明专利，ZL 2017 1 0383003.1。